Myeloid Leukemia : Methods and Protocols by Harry Iland
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Author: Harry Iland
Page Count: 320 pages
Published Date: 30 Nov 2005
Publisher: Humana Press Inc.
Publication Country: Totowa, NJ, United States
Language: English
ISBN: 9781588294852
File size: 9 Mb
File Name: myeloid.leukemia.methods.and.protocols.pdf
Download Link: myeloid leukemia methods and protocols
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A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia, classification of AML by DNA-oligonucleotide microarrays, and detection of the V617F JAK2 mutation in myeloproliferative disorders. In addition to gene rearrangements, other prognostically relevant molecular lesions such as FLT3 mutations and WT-1 overexpression are covered.
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